Hepatocyte polyploidization and its association with pathophysiological processes
نویسندگان
چکیده
منابع مشابه
Hepatocyte polyploidization and its association with pathophysiological processes
A characteristic cellular feature of the mammalian liver is the progressive polyploidization of the hepatocytes, where individual cells acquire more than two sets of chromosomes. Polyploidization results from cytokinesis failure that takes place progressively during the course of postnatal development. The proportion of polyploidy also increases with the aging process or with cellular stress su...
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Thyroid hormone regulation of rat hepatocyte proliferation and polyploidization.
The liver of adult mammals contains various classes of polyploid hepatocytes produced by a process that is partially regulated by hormones. However, it is not well understood how the hormones affect the rate of hepatocyte proliferation under physiological conditions. Here we have studied the specific roles of 3,5,3'-triiodothyronine (T3), growth hormone (GH), and sex steroids on the percentage ...
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ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2017
ISSN: 2041-4889
DOI: 10.1038/cddis.2017.167